The withdrawal of U.S. troops from Afghanistan in 2021 has not diminished the region’s importance in U.S. foreign policy, as indicated in the Biden-Harris National Security Strategy 2022. The U.S. aims to balance ongoing counterterrorism efforts against Al-Qaeda and Islamic State- Khorasan cells with pragmatic diplomacy, including potential engagement with the Taliban government. American policy towards Afghanistan will prioritize maintaining dominance in the face of emerging powers like Russia and China, while shaping major regional developments. Central Asian countries, particularly Uzbekistan, are emerging as crucial intermediaries for the United States in its nuanced approach towards Afghanistan. This approach involves tactical engagement to address immediate security concerns, alongside diplomatic isolationism to pressure the Taliban into making concessions regarding human rights and inclusive governance. The role of Uzbekistan has gained strategic significance for the United States due to its geographical proximity, shared values and traditions, and historical involvement in the region. Uzbekistan’s perspective prioritizes indirect engagement and regional partnerships to advance U.S. interests in the region, while incorporating Afghanistan into the regional framework.